Lexus RX vs Toyota Grand Highlander: Specs Compared

Running cost over five years: at the EPA's 15,000-mile-a-year assumption the Toyota Grand Highlander burns about $1,700 of fuel annually against $2,100 for the Lexus RX. That $400 yearly gap compounds to roughly $2,000 over five years and $3,200 over eight — often more than the price difference between two trims of the same vehicle, and the single largest running-cost line item separating these two.

City and highway economy: the Toyota Grand Highlander leads in both cycles — 37 mpg city and 34 mpg highway against 37 and 34 mpg — so its fuel-efficiency advantage holds whether you commute in traffic or cover long highway miles.

Powertrain choice: the Lexus RX is recorded with 4 distinct engine configurations (SIDI & PFI, SIDI & PFI; Hybrid, SIDI & PFI; PHEV), the Toyota Grand Highlander with 2 (SIDI & PFI, SIDI & PFI; Hybrid). Across 59 recorded Lexus RX configurations and 22 for the Toyota Grand Highlander, the wider the engine spread the more the real-world fuel efficiency depends on which version you actually buy, so check the specific model year and drivetrain rather than the headline number.

Drivetrain and class: the Lexus RX is offered with Front-Wheel Drive, All-Wheel Drive, the Toyota Grand Highlander with All-Wheel Drive, Front-Wheel Drive. All-wheel drive typically costs one to two mpg combined against the same vehicle in front- or rear-wheel drive, which is worth remembering when the gap between these two is small. The EPA classes them as Small Sport Utility Vehicle 4WD and Standard Sport Utility Vehicle 4WD respectively — the class drives the interior volume, cargo space and passenger space each one is measured against.

Tailpipe emissions: at their cleanest configurations the Lexus RX emits 89 g/mile of CO2 versus 246 g/mile for the Toyota Grand Highlander. Emissions track fuel consumption almost exactly, so the cleaner vehicle here is also the cheaper one to fuel.