Audi A4 vs Mercedes-Benz S-Class: Specs Compared

Running cost over five years: at the EPA's 15,000-mile-a-year assumption the Audi A4 burns about $2,450 of fuel annually against $2,900 for the Mercedes-Benz S-Class. That $450 yearly gap compounds to roughly $2,250 over five years and $3,600 over eight — often more than the price difference between two trims of the same vehicle, and the single largest running-cost line item separating these two.

City and highway economy: the Audi A4 leads in both cycles — 27 mpg city and 37 mpg highway against 24 and 31 mpg — so its fuel-efficiency advantage holds whether you commute in traffic or cover long highway miles.

Powertrain choice: the Audi A4 is recorded with 3 distinct engine configurations (SIDI; Mild Hybrid, SIDI, SIDI; FFV), the Mercedes-Benz S-Class with 4 (SIDI; Mild Hybrid, 6.0, SIDI; PHEV). Across 35 recorded Audi A4 configurations and 106 for the Mercedes-Benz S-Class, the wider the engine spread the more the real-world fuel efficiency depends on which version you actually buy, so check the specific model year and drivetrain rather than the headline number.

Drivetrain and class: the Audi A4 is offered with All-Wheel Drive, Front-Wheel Drive, the Mercedes-Benz S-Class with All-Wheel Drive, 4-Wheel Drive, Rear-Wheel Drive. All-wheel drive typically costs one to two mpg combined against the same vehicle in front- or rear-wheel drive, which is worth remembering when the gap between these two is small. The EPA classes them as Compact Cars and Large Cars respectively — the class drives the interior volume, cargo space and passenger space each one is measured against.

Tailpipe emissions: at their cleanest configurations the Mercedes-Benz S-Class emits 106 g/mile of CO2 versus 284 g/mile for the Audi A4. Emissions track fuel consumption almost exactly, so the cleaner vehicle here is also the cheaper one to fuel.