Acura TLX vs Audi A6: Specs Compared

Running cost over five years: at the EPA's 15,000-mile-a-year assumption the Audi A6 burns about $2,650 of fuel annually against $2,700 for the Acura TLX. That $50 yearly gap compounds to roughly $250 over five years and $400 over eight — often more than the price difference between two trims of the same vehicle, and the single largest running-cost line item separating these two.

City and highway economy: the Audi A6 leads in both cycles — 25 mpg city and 38 mpg highway against 24 and 35 mpg — so its fuel-efficiency advantage holds whether you commute in traffic or cover long highway miles.

Powertrain choice: the Acura TLX is recorded with 1 distinct engine configuration (SIDI), the Audi A6 with 3 (SIDI, SIDI; Mild Hybrid, 3.0). Across 50 recorded Acura TLX configurations and 36 for the Audi A6, the wider the engine spread the more the real-world fuel efficiency depends on which version you actually buy, so check the specific model year and drivetrain rather than the headline number.

Drivetrain and class: the Acura TLX is offered with Front-Wheel Drive, All-Wheel Drive, the Audi A6 with All-Wheel Drive, 4-Wheel Drive, Front-Wheel Drive. All-wheel drive typically costs one to two mpg combined against the same vehicle in front- or rear-wheel drive, which is worth remembering when the gap between these two is small. The EPA classes them as Compact Cars and Midsize Cars respectively — the class drives the interior volume, cargo space and passenger space each one is measured against.

Tailpipe emissions: at their cleanest configurations the Audi A6 emits 311 g/mile of CO2 versus 321 g/mile for the Acura TLX. Emissions track fuel consumption almost exactly, so the cleaner vehicle here is also the cheaper one to fuel.