Lexus IS vs Mercedes-Benz S-Class: Specs Compared

Running cost over five years: at the EPA's 15,000-mile-a-year assumption the Lexus IS burns about $2,900 of fuel annually against $2,900 for the Mercedes-Benz S-Class. That $0 yearly gap compounds to roughly $0 over five years and $0 over eight — often more than the price difference between two trims of the same vehicle, and the single largest running-cost line item separating these two.

City versus highway split: the Mercedes-Benz S-Class is the stronger commuter at 24 mpg city, while the Lexus IS pulls ahead on the interstate at 32 mpg highway. If most of your driving is stop-and-go traffic the city figure is the one to weigh; for long-distance highway mileage the reverse is true, and the two vehicles effectively swap places depending on how you drive.

Powertrain choice: the Lexus IS is recorded with 2 distinct engine configurations (SIDI & PFI, SIDI), the Mercedes-Benz S-Class with 4 (SIDI; Mild Hybrid, 6.0, SIDI; PHEV). Across 52 recorded Lexus IS configurations and 106 for the Mercedes-Benz S-Class, the wider the engine spread the more the real-world fuel efficiency depends on which version you actually buy, so check the specific model year and drivetrain rather than the headline number.

Drivetrain and class: the Lexus IS is offered with All-Wheel Drive, Rear-Wheel Drive, the Mercedes-Benz S-Class with All-Wheel Drive, 4-Wheel Drive, Rear-Wheel Drive. All-wheel drive typically costs one to two mpg combined against the same vehicle in front- or rear-wheel drive, which is worth remembering when the gap between these two is small. The EPA classes them as Compact Cars and Large Cars respectively — the class drives the interior volume, cargo space and passenger space each one is measured against.

Tailpipe emissions: at their cleanest configurations the Mercedes-Benz S-Class emits 106 g/mile of CO2 versus 345 g/mile for the Lexus IS. Emissions track fuel consumption almost exactly, so the cleaner vehicle here is also the cheaper one to fuel.