Infiniti QX50 vs Toyota Highlander: Specs Compared

Running cost over five years: at the EPA's 15,000-mile-a-year assumption the Toyota Highlander burns about $1,700 of fuel annually against $2,800 for the Infiniti QX50. That $1,100 yearly gap compounds to roughly $5,500 over five years and $8,800 over eight — often more than the price difference between two trims of the same vehicle, and the single largest running-cost line item separating these two.

City and highway economy: the Toyota Highlander leads in both cycles — 36 mpg city and 35 mpg highway against 24 and 31 mpg — so its fuel-efficiency advantage holds whether you commute in traffic or cover long highway miles.

Powertrain choice: the Infiniti QX50 is recorded with 3 distinct engine configurations (SIDI & PFI, SIDI & PFI; VCR, 3.7), the Toyota Highlander with 4 (SIDI & PFI; Hybrid, SIDI & PFI, SIDI & PFI; with Stop-Start). Across 20 recorded Infiniti QX50 configurations and 72 for the Toyota Highlander, the wider the engine spread the more the real-world fuel efficiency depends on which version you actually buy, so check the specific model year and drivetrain rather than the headline number.

Drivetrain and class: the Infiniti QX50 is offered with Front-Wheel Drive, All-Wheel Drive, Rear-Wheel Drive, the Toyota Highlander with All-Wheel Drive, Front-Wheel Drive. All-wheel drive typically costs one to two mpg combined against the same vehicle in front- or rear-wheel drive, which is worth remembering when the gap between these two is small. The EPA classes them as Small Sport Utility Vehicle 2WD and Standard Sport Utility Vehicle 4WD respectively — the class drives the interior volume, cargo space and passenger space each one is measured against.

Tailpipe emissions: at their cleanest configurations the Toyota Highlander emits 245 g/mile of CO2 versus 336 g/mile for the Infiniti QX50. Emissions track fuel consumption almost exactly, so the cleaner vehicle here is also the cheaper one to fuel.