Mercedes-Benz S-Class vs Porsche Panamera
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 25 mpg for the Porsche Panamera, a 1 mpg advantage and costs about $150 less per year to fuel.
Across 5 measured categories, the Mercedes-Benz S-Class leads in 5. Figures are EPA test data, not manufacturer claims.
2015–2027
Mercedes-Benz S-Class
Large Cars · 106 configurations
2015–2026
Porsche Panamera
Large Cars · 139 configurations
Head-to-head specifications
| Metric | Mercedes-Benz S-Class | Porsche Panamera |
|---|---|---|
| Best combined MPG | 26 mpg ✓ | 25 mpg |
| Best city MPG | 24 mpg ✓ | 23 mpg |
| Best highway MPG | 31 mpg ✓ | 29 mpg |
| Lowest annual fuel costEPA estimate at 15,000 miles per year | $2,900 ✓ | $3,050 |
| Lowest CO2 output | 106 g/mi ✓ | 185 g/mi |
| Engines offered | SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI | SIDI, SIDI; PHEV, 2.9, 4.0 |
| Transmissions | Automatic 9-spd, Automatic 7-spd | Automatic (AM-S8), Automatic (AM-S7) |
| Drivetrains | All-Wheel Drive, 4-Wheel Drive, Rear-Wheel Drive | All-Wheel Drive, Rear-Wheel Drive, 4-Wheel Drive |
| Fuel types | Premium, Premium and Electricity | Premium, Premium and Electricity, Premium Gas or Electricity |
| EPA class | Large Cars | Large Cars |
| Years covered | 2015–2027 | 2015–2026 |
| Configurations on record | 106 | 139 |
Source: EPA fuel economy records via fueleconomy.gov. Best-case values across all recorded configurations for each model.
S-Class vs Panamera: common questions
Which is better on gas, the Mercedes-Benz S-Class or the Porsche Panamera?
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 25 mpg for the Porsche Panamera, a 1 mpg advantage and costs about $150 less per year to fuel.
Which costs less to run per year?
By EPA estimates at 15,000 miles a year, the Mercedes-Benz S-Class runs about $2,900 a year in fuel at its most efficient configuration, versus about $3,050 for the Porsche Panamera — a difference of roughly $150 per year.
What engines do the S-Class and Panamera offer?
Mercedes-Benz S-Class: SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI. Porsche Panamera: SIDI, SIDI; PHEV, 2.9, 4.0.
Are they in the same vehicle class?
Yes — the EPA classifies both the Mercedes-Benz S-Class and the Porsche Panamera as Large Cars, so they compete directly.
More S-Class comparisons
Comparison id: mercedes-benz-s-class-vs-porsche-panamera