Mercedes-Benz S-Class vs Chrysler 300
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 23 mpg for the Chrysler 300, a 3 mpg advantage and costs about $250 less per year to fuel.
Across 5 measured categories, the Mercedes-Benz S-Class leads in 4. Figures are EPA test data, not manufacturer claims.
2015–2027
Mercedes-Benz S-Class
Large Cars · 106 configurations
Head-to-head specifications
| Metric | Mercedes-Benz S-Class | Chrysler 300 |
|---|---|---|
| Best combined MPG | 26 mpg ✓ | 23 mpg |
| Best city MPG | 24 mpg ✓ | 19 mpg |
| Best highway MPG | 31 mpg ✓ | 30 mpg |
| Lowest annual fuel costEPA estimate at 15,000 miles per year | $2,900 | $2,650 ✓ |
| Lowest CO2 output | 106 g/mi ✓ | 389 g/mi |
| Engines offered | SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI | 3.6, 5.7, 6.4, FFV |
| Transmissions | Automatic 9-spd, Automatic 7-spd | Automatic 8-spd |
| Drivetrains | All-Wheel Drive, 4-Wheel Drive, Rear-Wheel Drive | All-Wheel Drive, Rear-Wheel Drive |
| Fuel types | Premium, Premium and Electricity | Regular, Midgrade, Premium |
| EPA class | Large Cars | Large Cars |
| Years covered | 2015–2027 | 2015–2023 |
| Configurations on record | 106 | 38 |
Source: EPA fuel economy records via fueleconomy.gov. Best-case values across all recorded configurations for each model.
S-Class vs 300: common questions
Which is better on gas, the Mercedes-Benz S-Class or the Chrysler 300?
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 23 mpg for the Chrysler 300, a 3 mpg advantage and costs about $250 less per year to fuel.
Which costs less to run per year?
By EPA estimates at 15,000 miles a year, the Chrysler 300 runs about $2,650 a year in fuel at its most efficient configuration, versus about $2,900 for the Mercedes-Benz S-Class — a difference of roughly $250 per year.
What engines do the S-Class and 300 offer?
Mercedes-Benz S-Class: SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI. Chrysler 300: 3.6, 5.7, 6.4, FFV.
Are they in the same vehicle class?
Yes — the EPA classifies both the Mercedes-Benz S-Class and the Chrysler 300 as Large Cars, so they compete directly.
More S-Class comparisons
Comparison id: mercedes-benz-s-class-vs-chrysler-300