Mercedes-Benz E-Class vs Cadillac CT5
The Mercedes-Benz E-Class is the more efficient of the two: it reaches 28 mpg combined versus 27 mpg for the Cadillac CT5, a 1 mpg advantage and costs about $100 less per year to fuel.
Across 4 measured categories, the Mercedes-Benz E-Class leads in 4. Figures are EPA test data, not manufacturer claims.
2015–2027
Mercedes-Benz E-Class
Midsize Cars · 136 configurations
Head-to-head specifications
| Metric | Mercedes-Benz E-Class | Cadillac CT5 |
|---|---|---|
| Best combined MPG | 28 mpg ✓ | 27 mpg |
| Best city MPG | 25 mpg ✓ | 23 mpg |
| Best highway MPG | 33 mpg | 33 mpg |
| Lowest annual fuel costEPA estimate at 15,000 miles per year | $2,700 ✓ | $2,800 |
| Lowest CO2 output | 115 g/mi ✓ | 333 g/mi |
| Engines offered | SIDI; Mild Hybrid, SIDI; PHEV, SIDI, SIDI; FFV | SIDI |
| Transmissions | Automatic 9-spd, Automatic 7-spd | Automatic (S10), Manual 6-spd |
| Drivetrains | All-Wheel Drive, Rear-Wheel Drive, 4-Wheel Drive | All-Wheel Drive, Rear-Wheel Drive |
| Fuel types | Premium, Premium and Electricity, Premium or E85 | Premium |
| EPA class | Midsize Cars | Midsize Cars |
| Years covered | 2015–2027 | 2020–2026 |
| Configurations on record | 136 | 52 |
Source: EPA fuel economy records via fueleconomy.gov. Best-case values across all recorded configurations for each model.
E-Class vs CT5: common questions
Which is better on gas, the Mercedes-Benz E-Class or the Cadillac CT5?
The Mercedes-Benz E-Class is the more efficient of the two: it reaches 28 mpg combined versus 27 mpg for the Cadillac CT5, a 1 mpg advantage and costs about $100 less per year to fuel.
Which costs less to run per year?
By EPA estimates at 15,000 miles a year, the Mercedes-Benz E-Class runs about $2,700 a year in fuel at its most efficient configuration, versus about $2,800 for the Cadillac CT5 — a difference of roughly $100 per year.
What engines do the E-Class and CT5 offer?
Mercedes-Benz E-Class: SIDI; Mild Hybrid, SIDI; PHEV, SIDI, SIDI; FFV. Cadillac CT5: SIDI.
Are they in the same vehicle class?
Yes — the EPA classifies both the Mercedes-Benz E-Class and the Cadillac CT5 as Midsize Cars, so they compete directly.
More E-Class comparisons
Comparison id: mercedes-benz-e-class-vs-cadillac-ct5