Lexus IS vs Infiniti Q50

The Infiniti Q50 is the more efficient of the two: it reaches 31 mpg combined versus 26 mpg for the Lexus IS, a 5 mpg advantage and costs about $450 less per year to fuel.

Across 5 measured categories, the Infiniti Q50 leads in 5. Figures are EPA test data, not manufacturer claims.

2015–2026

Lexus IS

Compact Cars · 52 configurations

26mpg combined (best)
All Lexus IS specs

2015–2024

Infiniti Q50

Midsize Cars · 60 configurations

31mpg combined (best)
All Infiniti Q50 specs

Head-to-head specifications

MetricLexus ISInfiniti Q50
Best combined MPG26 mpg31 mpg
Best city MPG22 mpg29 mpg
Best highway MPG32 mpg36 mpg
Lowest annual fuel costEPA estimate at 15,000 miles per year$2,900$2,450
Lowest CO2 output345 g/mi286 g/mi
Engines offeredSIDI & PFI, SIDISIDI, 3.5, 2.0, 3.7
TransmissionsAutomatic (S6), Automatic (S8)Automatic (S7)
DrivetrainsAll-Wheel Drive, Rear-Wheel DriveAll-Wheel Drive, Rear-Wheel Drive
Fuel typesPremiumPremium
EPA classCompact CarsMidsize Cars
Years covered2015–20262015–2024
Configurations on record5260

Source: EPA fuel economy records via fueleconomy.gov. Best-case values across all recorded configurations for each model.

IS vs Q50: common questions

Which is better on gas, the Lexus IS or the Infiniti Q50?

The Infiniti Q50 is the more efficient of the two: it reaches 31 mpg combined versus 26 mpg for the Lexus IS, a 5 mpg advantage and costs about $450 less per year to fuel.

Which costs less to run per year?

By EPA estimates at 15,000 miles a year, the Infiniti Q50 runs about $2,450 a year in fuel at its most efficient configuration, versus about $2,900 for the Lexus IS — a difference of roughly $450 per year.

What engines do the IS and Q50 offer?

Lexus IS: SIDI & PFI, SIDI. Infiniti Q50: SIDI, 3.5, 2.0, 3.7.

Are they in the same vehicle class?

The EPA classifies the Lexus IS as Compact Cars and the Infiniti Q50 as Midsize Cars, so they aren't a like-for-like match on size.

More IS comparisons

Comparison id: lexus-is-vs-infiniti-q50