Chrysler 300 vs Mercedes-Benz S-Class
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 23 mpg for the Chrysler 300, a 3 mpg advantage and costs about $250 less per year to fuel.
Across 5 measured categories, the Mercedes-Benz S-Class leads in 4. Figures are EPA test data, not manufacturer claims.
2015–2027
Mercedes-Benz S-Class
Large Cars · 106 configurations
Head-to-head specifications
| Metric | Chrysler 300 | Mercedes-Benz S-Class |
|---|---|---|
| Best combined MPG | 23 mpg | 26 mpg ✓ |
| Best city MPG | 19 mpg | 24 mpg ✓ |
| Best highway MPG | 30 mpg | 31 mpg ✓ |
| Lowest annual fuel costEPA estimate at 15,000 miles per year | $2,650 ✓ | $2,900 |
| Lowest CO2 output | 389 g/mi | 106 g/mi ✓ |
| Engines offered | 3.6, 5.7, 6.4, FFV | SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI |
| Transmissions | Automatic 8-spd | Automatic 9-spd, Automatic 7-spd |
| Drivetrains | All-Wheel Drive, Rear-Wheel Drive | All-Wheel Drive, 4-Wheel Drive, Rear-Wheel Drive |
| Fuel types | Regular, Midgrade, Premium | Premium, Premium and Electricity |
| EPA class | Large Cars | Large Cars |
| Years covered | 2015–2023 | 2015–2027 |
| Configurations on record | 38 | 106 |
Source: EPA fuel economy records via fueleconomy.gov. Best-case values across all recorded configurations for each model.
300 vs S-Class: common questions
Which is better on gas, the Chrysler 300 or the Mercedes-Benz S-Class?
The Mercedes-Benz S-Class is the more efficient of the two: it reaches 26 mpg combined versus 23 mpg for the Chrysler 300, a 3 mpg advantage and costs about $250 less per year to fuel.
Which costs less to run per year?
By EPA estimates at 15,000 miles a year, the Chrysler 300 runs about $2,650 a year in fuel at its most efficient configuration, versus about $2,900 for the Mercedes-Benz S-Class — a difference of roughly $250 per year.
What engines do the 300 and S-Class offer?
Chrysler 300: 3.6, 5.7, 6.4, FFV. Mercedes-Benz S-Class: SIDI; Mild Hybrid, 6.0, SIDI; PHEV, SIDI.
Are they in the same vehicle class?
Yes — the EPA classifies both the Chrysler 300 and the Mercedes-Benz S-Class as Large Cars, so they compete directly.
More 300 comparisons
Comparison id: chrysler-300-vs-mercedes-benz-s-class